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dc.contributor.authorBraga, Antonio Limaen_US
dc.contributor.authorde Meneses, Ag-Anne Pereira Meloen_US
dc.contributor.authorSantos, Jose Victor de Oliveiren_US
dc.contributor.authordos Reis, Antonielly Campinhoen_US
dc.contributor.authorde Lima, Rosalia Maria Torresen_US
dc.contributor.authorda Mata, Ana Maria Oliveira Ferreiraen_US
dc.contributor.authorPaz, Marcia Fernanda Correia Jardimen_US
dc.contributor.authordos Santos Alves, Leane Brunelleen_US
dc.contributor.authorShaw, Subrataen_US
dc.contributor.authorUddin, Shaikh Jamalen_US
dc.contributor.authorRouf, Razinaen_US
dc.contributor.authorDas, Asish Kumaren_US
dc.contributor.authorDev, Shrabantien_US
dc.contributor.authorShill, Manik Chandraen_US
dc.contributor.authorShilpi, Jamil Aen_US
dc.contributor.authorKhan, Ishaq Nen_US
dc.contributor.authorIslam, Muhammad Torequlen_US
dc.contributor.authorAli, Eunus Sen_US
dc.contributor.authorMubarak, Mohammad Sen_US
dc.contributor.authorMishra, Siddhartha Kumaren_US
dc.contributor.authorde Castro e Souza, Joao Marceloen_US
dc.contributor.authorMelo-Cavalcante, Ana Amelia de Carvalhoen_US
dc.date.accessioned2019-02-14T03:57:58Z
dc.date.available2019-02-14T03:57:58Z
dc.date.issued2018-04-05
dc.identifier.citationBraga, A. L., de Meneses, A.-A. P. M., Santos, J. V. de O., dos Reis, A. C., de Lima, R. M. T., da Mata, A. M. O. F., … Melo-Cavalcante, A. A. de C. (2018). Toxicogenetic study of omeprazole and the modulatory effects of retinol palmitate and ascorbic acid on Allium cepa. Chemosphere, 204, 220–226. https://doi.org/10.1016/ j.chemosphere.2018.04.021en_US
dc.identifier.issn0045-6535
dc.identifier.urihttp://hdl.handle.net/2328/38953
dc.description© 2018 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (May 2018) in accordance with the publisher’s archiving policyen_US
dc.description.abstractOmeprazole (OME) is a proton pump inhibitor used for the treatment of various gastric and intestinal disease; however, studies on its effects on the genetic materials are still restricted. The present study aimed to evaluate possible toxicogenic effects of OME in Allium cepa meristems with the application of cytogenetic biomarkers for DNA damage, mutagenic, toxic and cytotoxic effects. Additionally, retinol palmitate (RP) and ascorbic acid (AA) were also co-treated with OME to evaluate possible modulatory effects of OME-induced cytogenetic damages. OME was tested at 10, 20 and 40 μg/mL, while RP and AA at 55 μg/mL and 352.2 μg/mL, respectively. Copper sulphate (0.6 μg/mL) and dechlorinated water were used as positive control and negative control, respectively. The results suggest that OME induced genotoxicity and mutagenicity in A. cepa at all tested concentrations. It was noted that cotreatment of OME with the antioxidant vitamins RP and/or AA significantly (p < 0.05) inhibited and/or modulated all toxicogenic damages induced by OME. These observations demonstrate their antigenotoxic, antimutagenic, antitoxic and anticitotoxic effects in A. cepa. This study indicates that application of antioxidants may be useful tools to overcome OME-induced toxic effects.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2018 Elsevier Ltd.en_US
dc.subjectAntioxidantsen_US
dc.subjectomeprazoleen_US
dc.subjectvitaminsen_US
dc.subjectAllium cepaen_US
dc.subjectcytogenotoxicityen_US
dc.titleToxicogenetic study of omeprazole and the modulatory effects of retinol palmitate and ascorbic acid on Allium cepaen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.chemosphere.2018.04.021en_US
dc.rights.holderElsevier Ltd.en_US


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