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dc.contributor.authorBaghdadi, Leena Ren_US
dc.contributor.authorWoodman, Richard Johnen_US
dc.contributor.authorShanahan, Ernst Michaelen_US
dc.contributor.authorWiese, Michael Den_US
dc.contributor.authorMangoni, Arduino Aleksanderen_US
dc.date.accessioned2019-02-27T23:05:15Z
dc.date.available2019-02-27T23:05:15Z
dc.date.issued2018-11-12
dc.identifier.citationBaghdadi, L., Woodman, R., Shanahan, E. M., Wiese, M., & Mangoni, A. (2018). Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study. Pharmacogenomics and Personalized Medicine, Volume 11, 205–210. https://doi.org/10.2147/pgpm.s170557en_US
dc.identifier.issn1178-7066
dc.identifier.urihttp://hdl.handle.net/2328/39023
dc.descriptionCreative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.en_US
dc.description.abstractPurpose: Methotrexate (MTX) treatment is associated with lower blood pressure (BP) and arterial stiffness in rheumatoid arthritis (RA). We investigated associations between single-nucleotide polymorphism (SNP) of the ATP-binding cassette efflux transporter gene ABCG2 (rs2231142), BP, and arterial stiffness in RA patients treated with MTX. Patients and methods: Clinical and 24-hour peripheral and central BP, arterial wave reflection (Augmentation Index, AIx), arterial stiffness (Pulse Wave Velocity, PWV), and intracellular MTX polyglutamate (MTXPGs) concentrations were assessed in 56 RA patients on stable treatment with MTX using a repeated cross-sectional study design with measurements at baseline and after 8 months. Results: Majority of the RA patients were homozygotes for the normal allele (CC, n=46) whereas 10 were rs2231142 heterozygotes (AC, n=10). MTXPGs concentrations were non-significantly higher in AC when compared to CC (144.3 vs 116.3 nmol/L packed RBCs, P=0.10). At baseline, the AC group had significantly lower age-adjusted clinical systolic BP (SBP) (P=0.01), 24-hour peripheral SBP (P=0.003), and central SBP (P=0.02) when compared to the CC group. However, AIx and PWV values were not significantly different between the two groups. When data from both visits were combined in a single analysis, and additionally adjusted for visit, gender, body mass index, and Disease Activity Score 28, the trend in SBP differences between-groups persisted but was no longer significant. Conclusion: Future studies are required to test the hypothesis that this genetic polymorphism is associated with lower BP, arterial stiffness, and possibly, cardiovascular risk, in RA patients treated with MTX.en_US
dc.language.isoenen_US
dc.publisherDove Pressen_US
dc.rights© 2018 Baghdadi et al.en_US
dc.subjectmethotrexateen_US
dc.subjectdisease-modifying antirheumatic drugsen_US
dc.subjectblood pressureen_US
dc.subjectaugmentation indexen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectpulse wave velocityen_US
dc.subjectsingle-nucleotide polymorphismsen_US
dc.subjectATP-binding cassette transportersen_US
dc.subjectABCG2en_US
dc.titleGenetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional studyen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.2147/pgpm.s170557en_US
dc.rights.holderBaghdadi et al.en_US
dc.rights.licenseCC-BY-NC
local.contributor.authorOrcidLookupMangoni, Arduino Aleksander: https://orcid.org/0000-0001-8699-1412en_US


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