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dc.contributor.authorKreuch, Deniseen_US
dc.contributor.authorKeating, Damien Johnen_US
dc.contributor.authorWu, Tongzhien_US
dc.contributor.authorHorowitz, Michaelen_US
dc.contributor.authorRayner, Christopher Ken_US
dc.contributor.authorYoung, Richard Len_US
dc.date.accessioned2019-03-07T05:23:29Z
dc.date.available2019-03-07T05:23:29Z
dc.date.issued2018-12-04
dc.identifier.citationKreuch D, Keating DJ, Wu T, Horowitz M, Rayner CK and Young RL (2018) Gut Mechanisms Linking Intestinal Sweet Sensing to Glycemic Control. Front. Endocrinol. 9:741. doi: 10.3389/fendo.2018.00741en_US
dc.identifier.issn1664-2392
dc.identifier.urihttp://hdl.handle.net/2328/39088
dc.descriptionCopyright © 2018 Kreuch, Keating, Wu, Horowitz, Rayner and Young. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.description.abstractSensing nutrients within the gastrointestinal tract engages the enteroendocrine cell system to signal within the mucosa, to intrinsic and extrinsic nerve pathways, and the circulation. This signaling provides powerful feedback from the intestine to slow the rate of gastric emptying, limit postprandial glycemic excursions, and induce satiation. This review focuses on the intestinal sensing of sweet stimuli (including low-calorie sweeteners), which engage similar G-protein-coupled receptors (GPCRs) to the sweet taste receptors (STRs) of the tongue. It explores the enteroendocrine cell signals deployed upon STR activation that act within and outside the gastrointestinal tract, with a focus on the role of this distinctive pathway in regulating glucose transport function via absorptive enterocytes, and the associated impact on postprandial glycemic responses in animals and humans. The emerging role of diet, including low-calorie sweeteners, in modulating the composition of the gut microbiome and how this may impact glycemic responses of the host, is also discussed, as is recent evidence of a causal role of diet-induced dysbiosis in influencing the gut-brain axis to alter gastric emptying and insulin release. Full knowledge of intestinal STR signaling in humans, and its capacity to engage host and/or microbiome mechanisms that modify glycemic control, holds the potential for improved prevention and management of type 2 diabetes.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relationhttp://purl.org/au-research/grants/nhmrc/627127en_US
dc.relationhttp://purl.org/au-research/grants/nhmrc/1081182en_US
dc.rightsCopyright © 2018 Kreuch, Keating, Wu, Horowitz, Rayner and Young.en_US
dc.subjectintestinal sweet taste receptorsen_US
dc.subjectL-cellsen_US
dc.subjectglucose transporten_US
dc.subjectSGLT-1en_US
dc.subjectglycemic controlen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.titleGut Mechanisms Linking Intestinal Sweet Sensing to Glycemic Controlen_US
dc.typeArticleen_US
dc.relation.grantnumberNHMRC/627127en_US
dc.relation.grantnumberNHMRC/1081182en_US
dc.identifier.doihttps://doi.org/10.3389/fendo.2018.00741en_US
dc.rights.holderKreuch, Keating, Wu, Horowitz, Rayner and Young.en_US


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