Phytol: A review of biomedical activities
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Date
2018-04-18Author
Islam, Muhammad Torequl
Ali, Eunus S
Uddin, Shaikh Jamal
Shaw, Subrata
Islam, Md Amirul
Ahmed, Md. Iqbal
Shill, Manik Chandra
Karmakar, Utpal Kumar
Yarla, Nagendra Sastry
Khan, Ishaq N
Billah, Md Morsaline
Pieczynska, Magdalena D
Malainer, Clemens
Nicoletti, Ferdinando
Gulei, Diana
Berindan-Neagoe, Ioana
Apostolov, Apostol
Yeung, Andy W K
Dey, Prasanta
Yele, Santosh
Jozwik, Artur
Strzalkowska, Nina
Marchewka, Joanna
Horbanczuk, Jaroslaw
Mubarak, Mohammad S
Shilpi, Jamil A
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Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
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© 2018 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 12 month embargo from date of publication (Auguist 2018) in accordance with the publisher’s archiving policy