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dc.contributor.authorIslam, Muhammad Torequlen_US
dc.contributor.authorAli, Eunus Sen_US
dc.contributor.authorUddin, Shaikh Jamalen_US
dc.contributor.authorShaw, Subrataen_US
dc.contributor.authorIslam, Md Amirulen_US
dc.contributor.authorAhmed, Md. Iqbalen_US
dc.contributor.authorShill, Manik Chandraen_US
dc.contributor.authorKarmakar, Utpal Kumaren_US
dc.contributor.authorYarla, Nagendra Sastryen_US
dc.contributor.authorKhan, Ishaq Nen_US
dc.contributor.authorBillah, Md Morsalineen_US
dc.contributor.authorPieczynska, Magdalena Den_US
dc.contributor.authorZengin, Gokhanen_US
dc.contributor.authorMalainer, Clemensen_US
dc.contributor.authorNicoletti, Ferdinandoen_US
dc.contributor.authorGulei, Dianaen_US
dc.contributor.authorBerindan-Neagoe, Ioanaen_US
dc.contributor.authorApostolov, Apostolen_US
dc.contributor.authorBanach, Maciejen_US
dc.contributor.authorYeung, Andy W Ken_US
dc.contributor.authorEl-Demerdash, Amren_US
dc.contributor.authorXiao, Jianboen_US
dc.contributor.authorDey, Prasantaen_US
dc.contributor.authorYele, Santoshen_US
dc.contributor.authorJozwik, Arturen_US
dc.contributor.authorStrzalkowska, Ninaen_US
dc.contributor.authorMarchewka, Joannaen_US
dc.contributor.authorRengasamy, Kannan R Ren_US
dc.contributor.authorHorbanczuk, Jaroslawen_US
dc.contributor.authorKamal, Mohammad Amjaden_US
dc.contributor.authorMubarak, Mohammad Sen_US
dc.contributor.authorMishra, Siddhartha Kumaren_US
dc.contributor.authorShilpi, Jamil Aen_US
dc.contributor.authorAtanasov, Atanas Gen_US
dc.date.accessioned2019-04-26T00:04:25Z
dc.date.available2019-04-26T00:04:25Z
dc.date.issued2018-04-18
dc.identifier.citationIslam, M. T., Ali, E. S., Uddin, S. J., Shaw, S., Islam, M. A., Ahmed, M. I., … Atanasov, A. G. (2018). Phytol: A review of biomedical activities. Food and Chemical Toxicology, 121, 82–94. https://doi.org/10.1016/j.fct.2018.08.032en_US
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/2328/39143
dc.description© 2018 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (Auguist 2018) in accordance with the publisher’s archiving policyen_US
dc.description.abstractPhytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2018 Elsevier Ltd.en_US
dc.subjectPhytolen_US
dc.subjectphytol metabolitesen_US
dc.subjectphytanic aciden_US
dc.subjectplant-derived compoundsen_US
dc.subjectbiological activitiesen_US
dc.titlePhytol: A review of biomedical activitiesen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.fct.2018.08.032en_US
dc.rights.holderElsevier Ltd.en_US
dc.rights.licenseCC-BY-NC-ND
local.contributor.authorOrcidLookupZengin, Gokhan: https://orcid.org/0000-0001-6548-7823en_US
local.contributor.authorOrcidLookupBanach, Maciej: https://orcid.org/0000-0001-6690-6874en_US
local.contributor.authorOrcidLookupEl-Demerdash, Amr: https://orcid.org/0000-0001-6459-2955en_US
local.contributor.authorOrcidLookupXiao, Jianbo: https://orcid.org/0000-0003-3311-770Xen_US
local.contributor.authorOrcidLookupRengasamy, Kannan R R: https://orcid.org/0000-0001-7205-7389en_US
local.contributor.authorOrcidLookupKamal, Mohammad Amjad: https://orcid.org/0000-0003-0088-0565en_US
local.contributor.authorOrcidLookupMishra, Siddhartha Kumar: https://orcid.org/0000-0003-1627-1377en_US
local.contributor.authorOrcidLookupAtanasov, Atanas G: https://orcid.org/0000-0003-2545-0967en_US


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