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dc.contributor.authorBorisjuk, Nikolaien_US
dc.contributor.authorKishchenko, Olenaen_US
dc.contributor.authorEliby, Seriken_US
dc.contributor.authorSchramm, Carlyen_US
dc.contributor.authorAnderson, Peter Alexen_US
dc.contributor.authorJatayev, Satyvaldyen_US
dc.contributor.authorKurishbayev, Akhylbeken_US
dc.contributor.authorShavrukov, Yurien_US
dc.date.accessioned2019-05-10T01:25:48Z
dc.date.available2019-05-10T01:25:48Z
dc.date.issued2019-03-10
dc.identifier.citationBorisjuk, N., Kishchenko, O., Eliby, S., Schramm, C., Anderson, P., Jatayev, S., … Shavrukov, Y. (2019). Genetic Modification for Wheat Improvement: From Transgenesis to Genome Editing. BioMed Research International, 2019, 1–18. https://doi.org/10.1155/2019/6216304en_US
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/2328/39196
dc.descriptionCopyright © 2019 Nikolai Borisjuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.description.abstractTo feed the growing human population, global wheat yields should increase to approximately 5 tonnes per ha from the current 3.3 tonnes by 2050. To reach this goal, existing breeding practices must be complemented with new techniques built upon recent gains from wheat genome sequencing, and the accumulated knowledge of genetic determinants underlying the agricultural traits responsible for crop yield and quality. In this review we primarily focus on the tools and techniques available for accessing gene functions which lead to clear phenotypes in wheat. We provide a view of the development of wheat transformation techniques from a historical perspective, and summarize how techniques have been adapted to obtain gain-of-function phenotypes by gene overexpression, loss-of-function phenotypes by expressing antisense RNAs (RNA interference or RNAi), and most recently the manipulation of gene structure and expression using site-specific nucleases, such as CRISPR/Cas9, for genome editing. The review summarizes recent successes in the application of wheat genetic manipulation to increase yield, improve nutritional and health-promoting qualities in wheat, and enhance the crop’s resistance to various biotic and abiotic stresses.en_US
dc.language.isoenen_US
dc.publisherHindawien_US
dc.rightsCopyright © 2019 Nikolai Borisjuk et al.en_US
dc.subjectWheat yieldsen_US
dc.subjectWheat genome sequencingen_US
dc.subjectGenetic determinantsen_US
dc.subjectWheat genetic manipulationen_US
dc.titleGenetic Modification for Wheat Improvement: From Transgenesis to Genome Editingen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1155/2019/6216304en_US
dc.date.updated2019-05-08T11:04:11Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holder2019 Nikolai Borisjuk et al.en_US
local.contributor.authorOrcidLookupShavrukov, Yuri: https://orcid.org/0000-0002-2941-0340en_US


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