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    • Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis 

      Carvalho, Marcelo; Couch, Fergus; Radice, Paolo; Monteiro, Alvaro; Karchin, Rachel; Grist, Scott Andrew; Gayol, Luis; Sali, Andrej; Goldgar, David; Marsillac, Sylvia; Baumbach, Lisa; Sutphen, Rebecca; Pickard-Brzosowicz, Jennifer; Manoukian, Siranoush; Swaby, Ramona; Silva, Rosane; Urmenyi, Turan; Rondinelli, Edson; Nathanson, Katherine (2007)
      Germ line inactivating mutations in BRCA1 confer susceptibility for breast and ovarian cancer. However, the relevance of the many missense changes in the gene for which the effect on protein function is unknown remains ...