Now showing items 58-77 of 205

    • Effect of cataract surgery incision location and intraocular lens type on ocular aberrations. [Post print] 

      Pesudovs, Konrad; Dietze, Holger; Stewart, Owen G; Noble, Bruce A; Cox, Michael J (Elsevier, 2005-04)
      PURPOSE: To determine whether Hartmann-Shack wavefront sensing detects differences in optical performance in vivo between poly(methyl methacrylate) (PMMA) and foldable acrylic intraocular lenses (IOLs) and between clear ...
    • Effectiveness of the community-based Low Vision Service Wales: a long-term outcome study 

      Ryan, Barbara; Khadka, Jyoti; Bunce, Catey; Court, Helen (BMJ Group, 2013-02-14)
      Aims To evaluate the long-term effectiveness of the community-based Low Vision Service Wales (LVSW). Methods A long-term observational study of the Government-funded, community-based, low-vision rehabilitation service ...
    • Epigenetic effects on eye diseases 

      Hewitt, Alex W; Wang, Jie Jin; Liang, Helena; Craig, Jamie E (Informa Plc, 2012-04)
      Epigenetics is the process by which patterns of gene expression are modified in a mitotically heritable manner. However, these epigenetic variations are not attributable to changes in the primary nucleotide sequence within ...
    • Establishing Levels of Indications for Cataract Surgery: Combining Clinical and Questionnaire Data into a Measure of Cataract Impact 

      McAlinden, Colm; Jonsson, M; Kugelberg, M; Lundstr, M; Khadka, Jyoti; Pesudovs, Konrad (Association for Research in Vision and Ophthalmology, Inc., 2012-03)
      Purpose.: To develop a model for establishing indications for cataract surgery that incorporates clinical and questionnaire data on a single linear scale using Rasch analysis. Methods.: In this prospective study, 293 ...
    • Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015 

      Wang, Haidong; Wolock, Tim M; Carter, Austin; Nguyen, Grant; Kyu, Hmwe Hmwe; Gakidou, Emmanuela; Hay, Simon I; Mills, Edward J; Trickey, Adam; Msemburi, William; Coates, Michael M; Mooney, Meghan D; Fraser, Maya S; Sligar, Amber; Salomon, Joshua; Larson, Heidi J; Friedman, Joseph; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abbas, Kaja M; El Razek, Mohamed Magdy; Abd-Allah, Foad; Abdulle, Abdishakur M; Abera, Semaw Ferede; Abubakar, Ibrahim; Pesudovs, Konrad; et. al. (Elsevier, 2016-01-19)
      Background Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of ...
    • Ethical Considerations for the Return of Incidental Findings in Ophthalmic Genomic Research 

      Souzeau, Emmanuelle; Burdon, Kathryn Penelope; Mackey, David A; Hewitt, Alex W; Savarirayan, Ravi; Otlowski, M; Craig, Jamie E (Association for Research in Vision and Ophthalmology (ARVO), 2016)
      Whole genome and whole exome sequencing technologies are being increasingly used in research. However, they have the potential to identify incidental findings (IF), findings not related to the indication of the test, raising ...
    • Evaluation of corneal transplantation 

      Coster, Douglas John (BMJ Publishing Group - http://bjo.bmjjournals.com/, 1997-08)
      Editorial / comment on corneal transplantation.
    • Expression of an anti-CD4 single-chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats 

      Appleby, Sarah Louise; Jessup, Claire Frances; Mortimer, Lauren A; Kirk, Kirsty; Brereton, Helen Mary; Coster, Douglas John; Tan, Chuan K; Williams, Keryn Anne (BMJ Group, 2012-11-21)
      To investigate whether expression of an anti-CD4 antibody fragment (scFv) by a lentivector-transduced donor cornea can prolong rat corneal allograft survival. Methods Inbred Fischer 344 rats received penetrating corneal ...
    • Gene therapy for corneal dystrophies and disease, where are we? 

      Williams, Keryn Anne; Klebe, Sonja (Lippincott Williams & Wilkins, 2012-07)
      We assess studies on vector systems for delivery of transgenes to the cornea that have been published over the last year, and summarise new work on the identification of specific transgenes for corneal diseases. Recent ...
    • Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. 

      Sharma, Shiwani; Burdon, Kathryn Penelope; Craig, Jamie E; Hewitt, Alex W; Wang, Jie Jin; Mackey, David A; Mitchell, Paul; McMellon, Amy E (2008)
    • The genetic and clinical landscape of nanophthalmos and posterior microphthalmos in an Australian cohort 

      Siggs, Owen M; Awadalla, Mona S; Souzeau, Emmanuelle; Staffieri, Sandra E; Kearns, Lisa A; Laurie, Kate; Kuot, Abraham; Qassim, Ayub; Edwards, Thomas L; Coote, Michael A; Mancel, Erica; Walland, Mark J; Dondey, Joanne; Galanopoulous, Anna; Casson, Robert J; Mills, Richard A; MacArthur, Daniel G; Ruddle, Jonathan B; Burdon, Kathryn P; Craig, Jamie E (Wiley, 2020-05)
      Nanophthalmos and posterior microphthalmos are ocular abnormalities in which both eyes are abnormally small, and typically associated with extreme hyperopia. We recruited 40 individuals from 13 kindreds with nanophthalmos ...
    • Genetic Association at the 9p21 Glaucoma Locus Contributes to Sex Bias in Normal-Tension Glaucoma 

      Ng, Soo Khai; Burdon, Kathryn Penelope; Fitzgerald, Jude T; Zhou, Tiger; Fogarty, Rhys Daniel; Souzeau, Emmanuelle; Landers, John; Mills, Richard Arthur; Casson, Robert J; Ridge, Bronwyn; Graham, Stuart L; Hewitt, Alex W; Mackey, David A; Healey, Paul R; Wang, Jie Jin; Mitchell, Paul; MacGregor, Stuart; Craig, Jamie E (Association for Research in Vision and Ophthalmology (ARVO), 2016)
    • Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci 

      Aung, Tin; Ozaki, Mineo; Lee, Mei Chin; Schlotzer-Schrehardt, Ursula; Thorleifsson, Gudmar; Mizoguchi, Takanori; Igo Jr, Robert P; Haripriya, Aravind; Williams, Susan E; Astakhov, Yury S; Orr, Andrew C; Burdon, Kathryn Penelope; Nakano, Satoko; Mori, Kazuhiko; Abu-Amero, Khaled; Hauser, Michael; Li, Zheng (Genome Institute Of Singapore); Prakadeeswari, Gopalakrishnan; Cooke-Bailey, Jessica N; Cherecheanu, Alina Popa; Kang, Jae Hee; Nelson, Sarah; Hayashi, Ken; Manabe, Shin-Ichi; Kazama, Shigeyasu; Zarnowski, Tomasz; Inoue, Kenji; Irkec, Murat; Coca-Prados, Miguel; Sugiyama, Kazuhisa; Jarvela, Irma; Schlottmann, Patricio; Lerner, S Fabian; Lamari, Hasnaa; Nilgun, Yildirim; Bikbov, Mukharram; Park, Ki Ho; Cha, Soon Cheol; Yamashiro, Kenji; Zenteno, Juan C; Jonas, Jost B; Kumar, Rajesh S; Perera, Shamira A; Chan, Anita S Y; Kobakhidze, Nino; George, Ronnie; Vijaya, Lingam; Do, Tan; Edward, Deepak P; Marcos, Lourdes De Juan; Pakravan, Mohammad; Moghimi, Sasan; Ideta, Ryuichi; Bach-Holm, Daniella; Kappelgaard, Per; Wirostko, Barbara; Thomas, Samuel; Gaston, Daniel; Bedard, Karen; Greer, Wenda L; Yang, Zhenglin; Chen, Xueyi; Huang, Lulin; Sang, Jinghong; Jia, Hongyan; Jia, Liyun; Qiao, Chunyan; Zhang, Hui; Liu, Xuyang; Zhao, Bowen; Wang, Ya Xing; Xu, Liang; Leruez, Stephanie; Reynier, Pascal; Chichua, George; Tabagari, Sergo; Uebe, Steffen; Zenkel, Matthias; Berner, Daniel; Mossbock, Georg; Weisschuh, Nicole; Hoja, Ursula; Welge-Luessen, Ulrich-Christoph; Mardin, Christian; Founti, Panayiota; Chatzikyriakidou, Anthi; Pappas, Theofanis; Anastasopoulos, Eleftherios; Lambropoulos, Alexandros; Ghosh, Arkasubhra; Shetty, Rohit; Porporato, Natalia; Saravanan, Vijayan; Venkatesh, Rengaraj; Shivkumar, Chandrashekaran; Kalpana, Narendran; Sarangapani, Sripriya; Kanavi, Mozhgan R; Beni, Afsaneh Naderi; Yazdani, Shahin; Lashay, Alireza; Naderifar, Homa; Khatibi, Nassim; Fea, Antonio; Lavia, Carlo; Dallorto, Laura; Rolle, Teresa; Frezzotti, Paolo; Paoli, Daniela; Salvi, Erika; Manunta, Paolo; Mori, Yosai; Miyata, Kazunori; Higashide, Tomomi; Chihara, Etsuo; Ishiko, Satoshi; Yoshida, Akitoshi; Yanagi, Masahide; Kiuchi, Yoshiaki; Ohashi, Tsutomu; Sakurai, Toshiya; Sugimoto, Takako; Chuman, Hideki; Aihara, Makoto; Inatani, Masaru; Miyake, Masahiro; Gotoh, Norimoto; Matsuda, Fumihiko; Yoshimura, Nagahisa; Ikeda, Yoko; Ueno, Morio; Sotozono, Chie; Jeoung, Jin Wook; Sagong, Min; Park, Kyu Hyung; Ahn, Jeeyun; Cruz-Aguilar, Marisa; Ezzouhairi, Sidi M; Rafei, Abderrahman; Chong, Yaan Fun; Ng, Xiao Yu; Goh, Shuang Ru; Chen, Yueming; Yong, Victor H K; Khan, Muhammad Imran; Olawoye, Olusola O; Ashaye, Adeyinka O; Ugbede, Idakwo; Onakoya, Adeola; Kizor-Akaraiwe, Nkiru; Teekhasaenee, Chaiwat; Suwan, Yanin; Supakontanasan, Wasu; Okeke, Suhanya; Uche, Nkechi J; Asimadu, Ifeoma; Ayub, Humaira; Akhtar, Farah; Kosior-Jarecka, Ewa; Lukasik, Urszula; Lischinsky, Ignacio; Castro, Vania; Grossmann, Rodolfo Perez; Megevand, Gordana Sunaric; Roy, Sylvain; Dervan, Edward; Silke, Eoin; Rao, Aparna; Sahay, Priti; Fornero, Pablo; Cuello, Osvaldo; Sivori, Delia; Zompa, Tamara; Mills, Richard Arthur; Souzeau, Emmanuelle; Mitchell, Paul; Wang, Jie Jin; Hewitt, Alex W; Coote, Michael; Crowston, Jonathan G; Astakhov, Sergei Y; Akopov, Eugeny L; Emelyanov, Anton; Vysochinskaya, Vera; Kazakbaeva, Gyulli; Fayzrakhmanov, Rinat; Al-Obeidan, Saleh A; Owaidhah, Ohoud; Aljasim, Leyla Ali; Chowbay, Balram; Foo, Jia Nee; Soh, Raphael Q; Sim, Kar Seng; Xie, Zhicheng; Cheong, Augustine W O; Mok, Shi Qi; Soo, Hui Meng; Chen, Xiao Y; Peh, Su Qin; Heng, Khai Koon; Husain, Rahat; Ho, Su-Ling; Hillmer, Axel M; Cheng, Ching-Yu; Escudero-Dominguez, F A; Gonzalez-Sarmiento, Rogelio; Martinon-Torres, Frederico; Salas, Antonio; Pathanapitoon, Kessara; Hansapinyo, Linda; Wanichwecharugruang, Boonsong; Kitnarong, Naris; Sakuntabhai, Anavaj; Nguyn, Hip X; Nguyn, Giang T T; Nguyn, Trinh V; Zenz, Werner; Binder, Alexander; Klobassa, Daniela S; Hibberd, Martin L; Davila, Sonia; Herms, Stefan; Nothen, Markus M; Moebus, Susanne; Rautenbach, Robyn M; Ziskind, Ari; Carmichael, Trevor R; Ramsay, Michele; Alvarez, Lydia; Garcia, Montserrat; Gonzalez-Iglesias, Hector; Rodriguez-Calvo, Pedro P; Fernandez-Vega Cueto, Luis; Oguz, Cilingir; Tamcelik, Nevbahar; Atalay, Eray; Batu, Bilge; Aktas, Dilek; Kasim, Burcu; Wilson, M Roy; Coleman, Anne L; Liu, Yutao; Challa, Pratap; Herndon, Leon; Kuchtey, Rachel W; Kuchtey, John (Nature Publishing Group, 2017-05-29)
      Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further ...
    • Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits 

      Grassmann, F; Kiel, C; Zimmermann, M E; Gorski, M; Grassmann, V; Stark, K; International AMD Genomics Consortium (IAMDGC); Souzeau, Emmanuelle; Heid, I M; Weber, B H F (BioMed Central, 2017-03-27)
      Background Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at ...
    • Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study 

      Baghdadi, Leena R; Woodman, Richard John; Shanahan, Ernst Michael; Wiese, Michael D; Mangoni, Arduino Aleksander (Dove Press, 2018-11-12)
      Purpose: Methotrexate (MTX) treatment is associated with lower blood pressure (BP) and arterial stiffness in rheumatoid arthritis (RA). We investigated associations between single-nucleotide polymorphism (SNP) of the ...
    • Genetic study of Diabetic Retinopathy: recruitment methodology and analysis of baseline characteristics 

      Kaidonis, Georgia; Abhary, Sotoodeh; Daniell, Mark; Gillies, Mark; Fogarty, Rhys Daniel; Petrovsky, Nikolai; Jenkins, Alicia; Essex, Rohan; Chang, John H; Pal, Bishwanath; Hewitt, Alex W; Burdon, Kathryn Penelope; Craig, Jamie E (Wiley-Blackwell, 2013-09-30)
      BACKGROUND: Diabetic retinopathy (DR) is a blinding disease of increasing prevalence, caused by a complex interplay of genetic and environmental factors. Here we describe the patient recruitment methodology, case and control ...
    • Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1 

      Burdon, Kathryn Penelope; MacGregor, Stuart; Hewitt, Alex W; Sharma, Shiwani; Chidlow, Glyn; Mills, Richard Arthur; Danoy, Patrick; Casson, Robert J; Viswanathan, Ananth C; Liu, Jimmy Z; Landers, John; Henders, Anjali K; Wood, John; Souzeau, Emmanuelle; Crawford, April; Leo, Paul; Wang, Jie Jin; Nyholt, Dale R; Martin, Nicholas G; Montgomery, Grant W; Mitchell, Paul; Brown, Matthew A; Mackey, David A; Craig, Jamie E (Nature Publishing Group, 2011)
      A genome-wide association study (GWAS) for open angle glaucoma (OAG) blindness was conducted using a discovery cohort of 590 cases with severe visual field loss and 3956 controls. Genome-wide significant associations were ...
    • Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma 

      MacGregor, Stuart; Ong, Jue Sheng; An, Jiyuan; Han, Xikun; Zhou, Tiger; Siggs, Owen M; Law, Matthew H; Souzeau, Emmanuelle; Sharma, Shiwani; Lynn, David J; Beesley, Jonathan; Sheldrick, Bronwyn; Mills, Richard Arthur; Landers, John; Ruddle, Jonathan B; Graham, Stuart L; Healey, Paul R; White, Andrew J; Casson, Robert J; Best, Stephen; Grigg, John RB; Goldberg, Ivan; Powell, Joseph E; Whiteman, David C; Smith, Graham; Martin, Nicholas G; Montgomery, Grant W; Burdon, Kathryn Penelope; Mackey, David A; Gharahkhani, Puya; Craig, Jamie E; Hewitt, Alex W (Springer Nature, 2018-07-27)
      Intraocular pressure (IOP) is currently the sole modifiable risk factor for primary open-angle glaucoma (POAG), one of the leading causes of blindness worldwide. Both IOP and POAG are highly heritable. We report a combined ...
    • Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia 

      Verhoeven, Virginie J M; Hysi, Pirro G; Wojciechowski, Robert; Fan, Qiao; Guggenheim, Jeremy A; Hohn, Rene; MacGregor, Stuart; Hewitt, Alex W; Nag, Abhishek; Cheng, Ching-Yu; Yonova-Doing, Ekaterina; Zhou, Xin (National University of Singapore); Ikram, M Kamran; Buitendijk, Gabrielle H S; McMahon, George; Kemp, John P; St Pourcain, St Pourcain; Simpson, Claire L; Mäkela, Kari-Matti; Lehtimaki, Terho; Kahonen, Mika; Paterson, Andrew D; Hosseini, S Mohsen; Wong, Hoi Suen; Xu, Liang; Jonas, Jost B; Pärssinen, Olavi; Wedenoja, Juho; Yip, Shea Yip; Ho, Daniel W H; Pang, Chi Pui; Chen, Li-Jia; Klein, Barbara E K; Klein, Ronald; Haller, Toomas; Metspalu, Andres; Khor, Chiea Chuen; Tai, E-Shyong; Aung, Tin; Vithana, Eranga; Tay, Wan-Ting; Barathi, Veluchamy A; Chen, Peng; Li, Ruoying; Liao, Jiemin; Zheng, Yingfeng (Singapore Eye Research Institute); Ong, Rick T; Döring, Angela; Evans, David M; Timpson, Nicholas J; Verkerk, Annemieke J M H; Meitinger, Thomas; Raitakari, Olli; Hawthorne, Felicia; Spector, Tim D; Karssen, Lennart C; Pirastu, Mario; Murgia, Federico; Ang, Wei; Mishra, Aniket; Montgomery, Grant W; Pennell, Craig E; Cumberland, Phillippa M; Cotlarciuc, Ioana; Mitchell, Paul; Wang, Jie Jin; Schache, Maria; Janmahasathian, Sarayut; Igo Jr, Robert P; Lass, Jonathan H; Chew, Emily; Iyengar, Sudha K; Gorgels, Theo G M F; Rudan, Igor; Hayward, Caroline; Wright, Alan F; Craig, Jamie E; Burdon, Kathryn Penelope (Nature Publishing Group, 2013-02-10)
      Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The CREAM consortium conducted genome-wide meta-analyses, ...
    • Geriatric Vision Care – a New Look at the Old 

      Leat, S; Gurwood, A; Kergoat, H; Pesudovs, Konrad; Eperjesi, F (Spanish Council of Optometry, 2009)
      World-wide, Optometry is expanding its scope of practice in many jurisdictions. The campaign to use therapeutic pharmaceutical agents (TPAs) is on-going in most countries and optometrists are increasingly becoming involved ...