Browsing Flinders Centre for Ophthalmology, Eye and Vision Research by Title
Now showing items 1-20 of 205
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Accurate Imputation-Based Screening of Gln368Ter Myocilin Variant in Primary Open-Angle Glaucoma
(Association for Research in Vision and Ophthalmology, 2015-08)PURPOSE: Myocilin (MYOC) is a well-established primary open-angle glaucoma (POAG) risk gene, with rare variants known to have high penetrance. The most common clinically relevant risk variant, Gln368Ter, has an allele ... -
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
(Nature Publishing Group, 2018-02-18)Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the ... -
Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs
(Elsevier, 2018-03-17)Purpose Diseases that involve retinal or choroidal vascular endothelial cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic vasculopathies, and noninfectious posterior uveitis. ... -
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity
(American Society for Clinical Investigation, 2016)Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in elevated ... -
Angiopoietin-1 is required for Schlemm’s canal development in mice and humans
(American Society for Clinical Investigation, 2017-11)Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm’s canal (SC) and the trabecular meshwork. We ... -
An Anti–VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea
(ARVO Journals, 2017-07)Purpose: We tested the ability of an antibody fragment with specificity for vascular endothelial growth factor-B (VEGF-B) to regress nascent and established corneal blood vessels in the rat. Methods: A single chain variable ... -
Apoptosis is a prominent feature of acute anterior uveitis in the Fischer 344 rat
(BMJ Publishing Group - http://bjo.bmjjournals.com/, 2000-02)AIMS: To examine the hypothesis that apoptosis of infiltrating cells contributes to spontaneous resolution of uveitis in clinically relevant rodent models. METHODS: Experimental melanin induced uveitis (EMIU) was induced ... -
Assessment of corneal thickness measurement using swept-source Fourier-domain anterior segment optical coherence tomography and Scheimpflug camera
(Elsevier, 2012-07-01)No abstract available -
Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration
(Nature Publishing Group, 2016)Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there ... -
Assessment of surgically induced astigmatism: toward an international standard II [comment.] [Post print]
(Elsevier, 1998-12)Letter in response to Holladay JT, Dudega DR, Koch DD "Evaluating and reporting astigmatism for individual and aggregate data", Journal of Cataract and Refractive Surgery, 1998, vol 24, 57-65 -
Assessment of surgically induced astigmatism: toward an international standard. [comment.] [Post print]
(Elsevier, 1998-12)Letter that recommends minimun data sets to be reported in studies of the changes in astigmatism brought about by surgery. -
Association of eNOS polymorphisms with primary angle-closure glaucoma
(Association for Research in Vision and Ophthalmology, 2013-03)Purpose: Recently, several studies have investigated genetic associations between Cytochrome P450 (CYP1B1), Endothelial nitric oxide synthase (eNOS) and Neurotrophin-4 (NTF4) with primary angle-closure glaucoma (PACG) in ... -
Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterisation of the protein in the eye
(Association for Research in Vision and Ophthalmology, 2012-06-06)Purpose. Glaucoma is the leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG) is the most common subtype. We recently reported association of genetic variants at chromosomal loci, 1q24 and ... -
Association of genetic variants with primary angle closure glaucoma in two different populations
(Public Library of Science, 2013)PURPOSE: A recent large genome-wide association study (GWAS) identified multiple variants associated with primary angle-closure glaucoma (PACG). The present study investigated the role of these variants in two cohorts ... -
Association of open-angle glaucoma loci with incident glaucoma in the Blue Mountains Eye Study.
(Elsevier Inc., 2015)PURPOSE: To determine if open-angle glaucoma (OAG)-associated single nucleotide polymorphisms (SNPs) are associated with incident glaucoma and if such genetic information is useful in OAG risk prediction. DESIGN: ... -
Australian and New Zealand Registry of Advanced Glaucoma: methodology and recruitment
(Wiley-Blackwell, 2013-08-13)Glaucoma is a sight-threatening disease affecting 3% of the population over the age of 50. Glaucoma is treatable, and severe vision loss can usually be prevented if diagnosis is made at an early stage. Genetic factors play ... -
The Australian Corneal Graft Registry 2004 annual report
(2006-06-20)The Australian Corneal Graft Registry (ACGR) opened in May 1985 and has now been in operation for 18 years. In that time, we have collected data on over 14,000 corneal grafts. At the time of transplantation, we seek ... -
The Australian Corneal Graft Registry 2007 Report
(Flinders University Press, 2007)The Australian Corneal Graft Registry opened in May 1985 and thus has now been in operation for over 22 years. The census date for this report was 01/09/2006. Over the years, we have collected data on more than 18,500 ... -
The Australian Corneal Graft Registry 2012 Report
(2012-03-05)The Australian Corneal Graft Registry (ACGR) opened in May 1985 and thus has now been in operation for over 26 years. However, the census dates for this report was 01/06/2010 for penetrating grafts and 12/10/2011 for ...